A number of enzymes that are important for signal transduction function when bound to the cell
membrane. The activity of these enzymes is regulated both by the properties of the membrane
as well as by specific signaling molecules and their location within membrane domains.
We are interested in the molecular mechanisms of the regulation of the activity of
these enzymes by lipid components.

References:

R.M. Epand, A.Kam, N. Bridgelal, A. Saiga and M Topham. 2004. The Epsilon Isoform of Diacylglycerol Kinase Exhibits Arachidonoyl-Specificity with Alkyl-Acyl Glycerol. Biochemistry, 43(46):14778-14783.

Fanani ML, Topham MK, Walsh JP, Epand RM. 2004. Lipid modulation of the activity of diacylglycerol kinase alpha- and zeta-isoforms: activation by phosphatidylethanolamine and cholesterol. Biochemistry, Nov 23;43(46):14767-77.

R.M. Epand, R. Cornell, S.M.A. Davies and R Kraayenhof.. Mechanism of the modulation of membrane interfacial enzyme catalysis by non-lamellar forming lipids: Comparison with the behavior of a fluorescent probe in membranes. In Fluorescence Spectroscopy, Imaging and Probes: New Tools in Chemical, Physical and Life Sciences, pp 263-276. Springer, Berlin 2002

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